Chemical biology technologies (Light driven, track cellular processes in real-time, and diagnose)

• Medicinal chemists and structural biologists often use this powerful technique to reveal molecular targets after phenotypic screens and investigate signaling pathways and interactions between proteins of interest. Fluorescent dyes and indicators, widely used in biolabeling. And the studies of protein-protein interactions (PPIs), Photoaffinity labeling has become one of the most used tools in chemical proteomics.
• Proximity Labeling (PL) and Photoaffinity Labeling (PAL) are both powerful chemical biology techniques used to map protein-protein interactions, but they differ fundamentally in how they interact with the target.
• Proximity Labeling (PL): Uses a targeted enzyme or photocatalyst to generate a cloud of reactive molecules that covalently tag surrounding proteins within a defined radius.
• Photoaffinity Labeling (PAL): Uses a small molecule or ligand engineered with a photoreactive group that covalently binds only to its direct interacting partners upon UV activation which can be further identified by mass-spec analysis and other methods.
• At Nuwa discovery, we have been working on synthesizing new Proximity Labeling (PL) and Photoaffinity Labeling (PAL) and operate in a flexible manner, offering our services in FTE and/or FFS mode